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Bioinformatics Research Initiative: Where'd that gene come from?

In partnership with WKU-O and Dr. Emani, LSA students will begin researching the origins of various genes via bioinformatics. Our intent is to present this research at the WKU Student Research Conference March 28, 2015 and eventually publish in a peer-reviewed journal. Once our work begins we will report on our progress and results here, so check back for updates!
Running Assignment Example

WKU-O Research Faculty

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Dr. Chandrakanth Emani
Ph.D. Osmania University
Assistant Professor of Plant Molecular Biology
Office:  WKU-Owensboro 109E
Phone:  (270) 852-6406
Email:  [email protected]
Curriculum Vitae

Research
Plant Genetic Engineering
  • Transgenic bamboo as a non-human model to understand the molecular basis of the non-neuronal acetylcholine pathway
  • Transgenic basil for production of the anti-cancerous compound eugenol
  • Transgenic sorghum and tobacco with Acidothermus cellulyticus cellulase gene – for utilization as biofuel enzyme sources
Plant Molecular Evolution
  • Tracing the evolution of acetylcholine pathway enzymes choline acetyltransferase and acetylcholine esterase across life forms with bamboo as a reference
  • Utilizing phylogenetic analysis to trace the molecular evolution of eugenol synthase in plants with basil as a reference
Biology History and Philosophy
Using episodic history in biology to instill scientific thought process in classroom and educating the general public about scientific method and scientific thinking
Articles from the Messenger Inquirer by Dr. Emani
Scientists and Soldiers
A Monk in a Pea Garden
Baby
Corn Cobs & Nobel Prizes
Father of Social Medicine
Lasik
Mad Dogs, Broccoli and a Little Book
Petunias
The Book of Life
We are all Scientists
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Assignment 1: Identify your gene of interest
Thyroid- Thyroid adenoma isaform a Homo sapien
Asthma- Interleukin 13 Homo sapien
Alzheimer's- Presenelin 2 (Alzheimer disease 4) Isoform CRA_a Homo sapien
Cancer- p53 Homo sapien
Schizophrenia- disrupted in schizophrenia 1 protein isoform L Homo sapien
Narcolepsy- Orexin precursor Homo sapien
Tay Sachs- Chain A Native human Lysosomal  B- Hex Isoform B Homo sapien
HIV- CCR5 Homo sapien
Breast Cancer- BRCA1 Homo sapien
Leukemia- chronic lymphocytic leukemia up-regulated protein 1 Homo sapien
Infertility- ubiquitin carboxyl-terminal hydrolase 26 Homo sapien
Assignment 2: 
1) Copy/Paste the FASTA sequence for your gene.
2) Run a blast and distance tree of results. Record the scientific and common name of of the most ancestral species discovered on the tree.
3) Click the domain name and copy/paste the information pictured at the top of the page. 

Assignment 3: 
1) Brainstorm! How would your ancestor have developed the disease? 
2) Get an image of your protein.
3) Run 2 more iterations.
4) Find at least 15 sequences as part of the organism report

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